Endocrine Abstracts

We present an 83-year-old female who presented with excess body hair growth, worst on her face, arms and abdomen. This was associated with features of virilasation and weight loss. Her past medical history includes; hypertension, Temporal arteritis, Gout and duodenal ulcer disease. Her medications were Felodipine 2.5 mg OD, Captopril 25 mg BD, Bendroflumethiazide 2.5 mg OD, Aspirin 75 mg OD, Ezmoprazole 20 mg OD.On examination, she was found to have deep...

A 36 year old lady referred to the endocrinology clinic, with a history of tiredness, fatigability and abnormal thyroid function. She had no significant past medial history, no family history of thyroid disease and her only medication was an oral contraceptive pill (Ovranette). She had experienced fatigue over a period of 5 years, since returning from a visit to Pakistan, during which she had developed diarrhoea which had persisted for about 12 months. Thyroid function tests a...

The efficacy of dopamine agonist therapy for complex solid and cystic macroprolactinoma is a subject of controversy among endocrinologists. Many believe that such therapy may not result in a clinically significant shrinkage of any cystic component of a macroprolactinomas.We present a case of cystic macroprolactinoma which responded damatically to dopaminergic therapy with recovery of pituitary function.A 22 years old male, presente...

Growth hormone replacement has not been recommended for use during pregnancy, due to lack of controlled trials to study its effects on the mother and the baby. We present a patient with hypopitiutarism on rhGH replacement which was continued during pregnancy with no adverse effects.A 35 years old lady, diagnosed ages 30 with pan-hypopituitarism secondary to non-functioning pituitary adenoma, she underwent trans-sphenoidal resection of the adenoma in 2002...

Back ground: Radio iodine treatment is widely used in the management of hyperthyroidism. Recent guidelines have stressed the importance of advising patients of the recommendations with regard to radiation protection, and the implications of radioiodine treatment in relation to work, travel and contact with the family. We carried out a survey to assess our joint radioiodine clinic approach where all patients referred for treatment are assessed jointly by a consultant endocrinol...

Introduction: Prostate carcinoma is a recognised yet rare cause of Cushing’s syndrome. This report describes two cases in which Cushing’s syndrome was associated with advanced prostate cancer.Case 1: A 70-year man presented with a very short history of swelling of his face and legs. He was known to have prostate adenocarcinoma with bony metastases. He was hypokalaemic and resistant to standard potassium replacement. He had a Cushingoid appearan...

FNA of the thyroid is used for fast and early assessment of thyroid nodules, however it is sensitivity as a useful diagnostic test depends largely on the technique, experience of the aspirator and expertise of the cytologist. We undertook a retrospective audit of FNA to evaluate our results and compliance with the national guidelines.We examined 121 patients had FNAs at Pinderfields Hospital from October 2000 to June 2007. The cohort was comprised of 106...

Patients with GHD have an, adverse body composition, insulin resistance, atherogenic lipid profile and impaired quality of life. We undertook a single centre retrospective audit of hypopituitary adults to quantify the long-term effects of dose-titrated GH replacement.The cohort comprised 53 patients defined as severely GHD using the GST (median peak GH 2.4 μ/l). Mean age 42±16.9 years, 23F, BMI 29.3±5.3 kg/m2. GH was titrated un...